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Analysis of the principle of LC/MS
Mass spectrometry is an analytical method that first ionizes a substance, separates it according to the mass-to-charge ratio of the ion, and then measures the intensity of various ion peaks for analysis purposes. Samples of mass spectrometry are typically vaporized and then ionized. Impurity samples are processed by chromatography and mass spectrometry using a chromatographic and mass spectrometer. That is, chromatographic separation, and mass spectrometry is a chromatographic detector. Under the combined action of the electric field and the magnetic field, the ions are sequentially arranged according to the ratio of the mass number m and the charge number Z (m/z, mass-to-charge ratio). The spectrum is recorded as the intensity of the ion signal detected by the detector. The bar graph made by the coordinates and the ion mass-to-charge ratio as the abscissa is our common mass spectrum.