After more than three years of research, the research team of Professor Ma Lan of the Institute of Brain Science of Fudan University has recently discovered the function of a protein kinase GRK5 that is widespread in the body in the nervous system, and a new mechanism for regulating neuronal morphology and plasticity, which will give nerves The development and drug development of diseases such as autism and Down syndrome caused by meta-developmental abnormalities provide new ideas. The discovery was recently published in the internationally renowned academic journal "Cell Biology". Neurons, also called nerve cells, are the basic units that make up the structure and function of the nervous system. Tens of millions of neurons in the brain are the basic and basic unit for forming brain functions such as emotion, memory and consciousness. The formation and remodeling of brain neural networks depend on the morphogenesis and dynamic changes of neurons. Both neuronal cytoskeletal remodeling and cytoplasmic membrane deformation play an important role in neuronal morphogenesis and dynamic changes, but how do neurons coordinate cytoplasmic membrane deformation and cytoskeletal remodeling to promote neurite outgrowth The connection with neurons has always been a mystery. Young researchers Chen Yuejun, Wang Feifei and Long Hui from the Malan Research Group obtained an unexpected answer through biochemistry, cell and animal experiments: GRK5 can play a role as a bridge in the nervous system in another way, that is, one end of GRK5 can be connected to the brain The combination of internal cytoskeleton causes cytoskeletal remodeling. At the other end, it can guide the reconstructed cytoskeleton to the PIP2-enriched cytoplasmic membrane area by binding the specific phospholipid "PIP2" on the neuronal cell membrane in the brain to coordinate cells Skeletal reconstruction and cell membrane deformation promote neuronal morphological changes and the formation of connections between neurons. Chen Yuejun told reporters that many diseases that affect cognition, such as autism, mental retardation, fragile syndrome, Down syndrome, etc., are accompanied by abnormal neuronal morphological development. Their research found that GRK5 has new functions to promote neuronal morphological development, proving that GRK5 is an important protein that promotes the formation of neural networks and regulates brain learning and memory functions. It is a treatment and drug development for mental disorders caused by abnormal neuronal development. Provided new targets. (Reporter Wang Chun from Sun Guogen) Pvc Fence Gate,Pvc Portable Fence,Picket Fence Gate,Plastic Fence Gate ZHEJIANG DEQING GONAT FENCE CO.,LTD , https://www.gonatfence.com