Researchers from the Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine and the Affiliated Hospital of Changchun University of Traditional Chinese Medicine published the title "Clinical Characteristics and Genetic Profiles of 44 Patients with Severe Combined Immunodeficiency (SCID): Report from Shanghai, China (2004C2011 ) "Article, for the first time in the world, analyzed a rare disease: severe combined immunodeficiency disease (SCID) mutations in the Chinese population, and the first report of the clinical characteristics of this disease in China. Relevant achievements were published in the Journal of Clinical Immunology, an international authoritative journal in the field of clinical immunology. The corresponding author of the article is Professor Chen Tongxin, Director of the Immunology Department of the Children's Medical Center, Shanghai Jiaotong University School of Medicine. Professor Chen has been engaged in the research and diagnosis and treatment of clinical diseases in pediatrics for nearly 30 years. Significant results have been achieved in the diagnosis and treatment of diseases and rheumatism. Severe combined immunodeficiency disease is a group of primary immunodeficiency diseases that seriously threaten children's health. It is characterized by a lack or abnormality of T lymphocytes, with or without B lymphocytes and natural killer cells. Group of diseases. The onset of the disease is early, the clinical manifestations are severe, and the prognosis is poor. If not diagnosed and treated in time, most of the children die within 1 year of age. At present, the disease has been listed as an "emergency case" abroad. Once the diagnosis is confirmed, hematopoietic stem cell transplantation is required immediately to win new life for the child in time. In this article, the researchers analyzed the clinical characteristics and gene mutation characteristics of children with severe combined immunodeficiency in children from 2004 to 2011. They have accumulated through 8 years of clinical work, from gender composition, age of onset, The clinical manifestations, hematopoietic stem cell transplantation, and prognosis were analyzed in 44 cases of severe combined immunodeficiency disease (SCID) in children with clinical characteristics and gene mutation characteristics, and 11 new mutation genes that have never been reported in the world were found. It has enriched the gene pool of severe combined immunodeficiency disease mutations. Since SCID is a rare disease, 44 cases are reported to be a large sample study even internationally. Once this study is published, it is highly evaluated by international peers. Relevant experts believe that this article has important reference significance for understanding the clinical characteristics and gene mutation characteristics of children with severe combined immunodeficiency disease in China, as well as for their early intervention and early treatment. The publication of this article will also play a positive role in promoting and promoting the diagnosis of early severe combined immunodeficiency disease, hematopoietic stem cell transplantation and neonatal disease screening, as well as infant and young child health protection. Professor Chen Tongxin took the lead in carrying out immunotyping and genetic diagnosis of primary immunodeficiency disease in China, and published more than 10 related articles in foreign SCI journals, undertook the investigation of WHO's primary immunodeficiency disease poliovirus carrying , Led to the establishment of a special fund for the treatment of primary immunodeficiency diseases in the Shanghai Children's Hospitalization Fund. In addition, its research team has also successfully used hematopoietic stem cells to treat congenital immunodeficiency for the first time. Congenital immunodeficiency is a genetic disease that usually occurs in infancy and childhood. There are more than 150 types of congenital immunodeficiency diseases that have been identified, and they are high-incidence diseases among genetic diseases. Professor Chen Tongxin confirmed after 7 months of follow-up that a 22-year-old patient with congenital immunodeficiency has successfully rebuilt his own immune system. Of patients. About the Author: Chen Tongxin, male, chief physician, professor, doctoral tutor, mainly engaged in the clinical and research work of clinical immunology and pediatric hematological oncology. The research on primary immunodeficiency disease is at the domestic leading level, and is currently engaged in viral infections. Study on the differentiation and function of neonatal dendritic cells. Has completed and is undertaking 9 national-level and Shanghai projects, won 1 third prize of Shanghai Science and Technology Achievement Award, 2 third prizes of Shanghai Medical Science and Technology Achievement Award, and published more than 50 papers in domestic and foreign journals , Participated in editing 6 books. Currently serves as the deputy head of the immunology group of the Pediatrics Specialty Committee of the Chinese Medical Association, the deputy director of the Clinical Immunology Branch of the Chinese Immunology Society, the executive director and secretary-general of the Shanghai Immunology Society, the reviewing expert of the National Natural Science Foundation of China, and the medical accident technical identification of the Chinese Medical Association Expert, expert on special allowance from the State Council, editorial board member of Chinese Pediatrics, international member of American Academy of Allergy, Asthma and Immunology, and invited expert reviewer of British Journal of Hematology. Beach Racket,Racquet Beach Tennis,Wooden Beach Tennis Rackets,Professional Beach Tennis Rackets Ningbo Sno Stationery & Sports Articles Co., Ltd. , https://www.snoflyingdisc.com