Tetraspira DNA found in human cancer cells

Because cancer cells divide very quickly and defects often appear at the ends of chromosomes, the DNA molecule of the quartet may be the only one present in cancer cells. If this is the case, any cancer treatment will not harm healthy cells. "I hope this latest discovery will challenge our dogmatic understanding of the structure of DNA," said Shanka-Barasuburamani of Cambridge University in the UK.

Balasubramani led a research team to discover the presence of quadruplex DNA in cancer cells when using antibiotics. In order to prevent the breakdown of quadrispira to ordinary DNA, they brought this DNA molecule into contact with the antibiotic pyridostatin. Antibiotics are able to keep the four-stranded spirochete in the area where it is produced. This study allows researchers to calculate the number of cells formed at various stages of cell proliferation. The DNA of quadrispira is abundant in the S phase (the stage of DNA replication before cell division).

Balasubramani said: "I guess that there are also four-stranded spirochete molecules in normal cells, but they are different from cancer cells. It is likely that the four-stranded spirochete molecules are reorganized in the disordered genome and cancerous or precancerous cells Under the circumstances, "said Julie Sharp of the British Cancer Research Center:" This study will further emphasize the potential of these unique DNA structures to treat cancer. Next, we will study how to find the quadruplex helix molecule in tumor cells.

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